Reynolds JV, Shaun RP, Brian O, Maeve AL, Lene B, Thomas C, et al. Intrathoracic vs cervical anastomosis after totally or hybrid minimally invasive esophagectomy for esophageal cancer. Workum F, van, Verstegen MHP, Klarenbeek BR, Bouwense SAW, Henegouwen MI, van B, et al. Benchmarking complications associated with esophagectomy. Low DE, Kuppusamy MK, Alderson D, Cecconello I, Chang AC, Darling G, et al. Esophageal and Esophagogastric Junction Cancers, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology. 2019 57:e120.Ījani JA, D’Amico TA, Bentrem DJ, Chao J, Corvera C, Das P, et al. Longterm results of a randomized trial of surgery with or without preoperative chemotherapy in esophageal cancer. Oesophageal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Lordick F, Mariette C, Haustermans K, Obermannová R, Arnold D. Poor survival in the high-risk group highlights need for adjuvant therapy. Histopathologic regression and nodal status should be combined for estimating AC and SCC prognosis. Median survival in AC and SCC cohorts were comparable (3.8 (CI 95%: 3.1, 5.3) vs. Survival analysis identified three groups with significantly different mortality risks: (1) low-risk group for CR (ypT0N0) with 72% 5-year overall survival (5y-OS), (2) intermediate-risk group for minor/major responders and ypN0 with 59% 5y-OS, and (3) high-risk group for minor/major responders and ypN+ with 20% 5y-OS ( p < 0.001). Kaplan–Meier and Cox regression were used for survival analysis. Nodal stage was classified as ypN0 and ypN+. Histopathologic response was classified according to percentage of vital residual tumour cells (VRTC): complete response (CR) without VRTC, major response with 10% VRTC. Seven hundred and fifteen patients with oesophageal squamous cell (SCC) or adenocarcinoma (AC) undergoing NT and esophagectomy were analysed. Here, a score combining both to improve prediction of survival after neoadjuvant therapy is developed. Histopathologic regression following neoadjuvant treatment (NT) of oesophageal cancer is a prognostic factor of survival, but the nodal status is not considered.
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